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The first angel poured out his vial on earth

Revelation 16: 1 – 2

And I heard a great voice out of the temple, speaking to the seven angels: Go your ways, and pour out the seven vials full of the willpower of God upon the earth!

And there fell ulcers, painful and malignant, upon men, which had the mark of the beast, and upon them which had to worship his image.

And the first went, and poured out his vial upon the earth.

And I heard a great voice out of the temple, speaking to the seven angels: Go your ways, and pour out the seven vials full of the willpower of God upon the earth! 

And the first went, and poured out his vial upon the earth.

And there fell ulcers, painful and malignant, upon men, which had the mark of the beast, and upon them which had to worship his image.

In art

Revelation 16: 1 – 2

Saint-Sever Beatus, 11th century, 1st angel poured out bowl and people got sores.